Differentiating the Various Rare Lymphatic Anomalies: GLA, GSD, KLA


Presented by Ionela Iacobas, MD, Assistant Professor of Pediatric Hematology-Oncology and Medical Director, TCH Vascular Anomalies Center, Texas Children’s Hospital, Baylor College of Medicine

Abstract: A new diagnosis of lymphatic malformation presenting with a micro/macrocystic area AND an additional symptom may trigger very specific diagnostic studies for clear classification. This discussion will try to differentiate the 4 entities (Generalized Lymphatic Anomaly, Gorham-Stout Disease, Kaposiform Lymphangiomatosis and Central Conducting Lymphatic Anomaly) based on clinical features, imaging and coagulopathy. It will particularly focus on bone lesions, effusions, associated lymphedema and risk of bleeding. Assigning the correct diagnosis has clear, practical implications into the procedural and medical management, in the screening for complications and even prognosis.


 


About the Presenter

Dr. Ionela Iacobas is the medical director of the Vascular Anomalies Center and Co-Director of the Pediatric Hematology-Oncology Vascular Anomalies Program at Texas Children’s Hospital. Her main interest is to offer children and young adults with vascular anomalies state-of-the-art medical management in a comprehensive approach. Ranging from venous or lymphatic malformations to metastatic vascular tumors, the Vascular Anomalies Program uses anticoagulants (like low molecular weight heparin), immunosupressants (like sirolimus), chemotherapy, etc. to treat a large variety of vascular anomalies.

Dr. Iacobas believes that children with vascular tumors and malformations need more than just invasive procedures and medications, so her team involves the major supportive services (including physical therapy, social work, child life, psychology, pain management, orthotics – compression garments, support groups, etc).

As education and research in the vascular anomalies field are essential for best patient care, Dr. Iacobas is very active at the national level as Chair of the Education Committee of the Vascular Anomalies Specific Interest Group of ASPHO, where she is developing educational resources and a curriculum for hematology-oncology physicians who are interested in vascular anomalies.

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